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- Title
经皮锁定钢板内固定治疗胫骨骨折的疗效及对患者血清IGF-1,TGF-β1及BGP水平的影响
- Authors
李育刚; 许泽川; 常山; 曾智谋; 杨红胜
- Abstract
Objective: To research the clinical effect of percutaneous locking plate fixation on the treatment of tibial fracture and serum levels of IGF-1, TGF-β1 and BGP in patients. Metfiods: 90 patients with fracture tibia were divided into the control group (n=45) and the experimental group (n=45). The patients in the control group were treated with open reduction and anatomical plate internal fixation, while the patients in the experimental group were treated with percutaneous locking plate internal fixation. Then the serum levels of insulin-like growth factor-1(IGF-1), transforming growth factor-β1 (TGF-β1) and BGP (osteocalcin), the incision length, intraoperative blood loss, hospitalization, fracture healing time, clinical curative effect and postoperative complications were observed and compared between the two groups before and after the treatment. Results: A fter treatment, the serum levels of IGF-1, TGF-β1 and BGP in the experimental group were higher than those of the control group, and the differences were statistically significant (P<0.05). The incision length, intraoperative blood loss, hospitalization and fracture healing time of the experimental group were less than those of the control group, and the differences were statistically significant (P<0.05). The excellent and recovery rate of the experimental group was higher than that of the control group, and the differences were statistically significant (P<0.05). The postoperative complications of the experimental group was lower than that of the control group, and the differences were statistically significant (P<0.05). Conclusion: Percutaneous locking plate fixation has obvious effect on the treatment of tibial fractures, which can increase the serum levels of IGF-1, TGF-β1 and BGP and promote the functional recovery ofpatients.
- Subjects
TIBIAL plateau fractures; SOMATOMEDIN C; TRANSFORMING growth factors; OSTEOCALCIN; SURGICAL complications
- Publication
Progress in Modern Biomedicine, 2017, Vol 17, Issue 17, p3306
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2017.17.026