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- Title
Follicular Regulatory T Cells in Systemic Lupus Erythematosus.
- Authors
Xia, Xin; Yang, Jun; Wang, Shengjun
- Abstract
Follicular regulatory T (Tfr) cells are the regulatory T cell subset mainly localized in the germinal center (GC), acting as modulators of GC responses. They can disrupt Tfh cell- and B cell-linked recognition, induce Tfh apoptosis, and suppress B cell function. Evidences show that dysregulated Tfr cells are associated with the disease activity index and serum autoantibody levels, influencing the development of systemic lupus erythematosus (SLE). This review focuses on the interaction among Tfr, Tfh, and B cells, summarizes the characterization and function of Tfr cells, concludes the imbalance of CD4+T subsets in SLE, and presents potential therapies for SLE. In general, we discuss the roles of Tfr cells in the progress of SLE and provide potential treatments.
- Subjects
REGULATORY T cells; SYSTEMIC lupus erythematosus; B cells; CELL physiology; GERMINAL centers
- Publication
Journal of Immunology Research, 2021, p1
- ISSN
2314-8861
- Publication type
journal article
- DOI
10.1155/2021/9943743