We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Predictors of uropathogens other than Escherichia coli in patients with community-onset acute pyelonephritis.
- Authors
Wi, Y. M.; Kim, S.‐W.; Chang, H.‐H.; Jung, S.‐I.; Kim, Y.‐S.; Cheong, H. S.; Ki, H. K.; Son, J. S.; Kwon, K. T.; Heo, S. T.; Yeom, J.‐S.; Ko, K. S.; Kang, C. I.; Chung, D. R.; Peck, K. R.; Song, J.‐H.
- Abstract
Aim A constant reduction in the incidence of community-onset acute pyelonephritis ( CO- APN) caused by Escherichia coli has been shown with a parallel increase incidence caused by other organisms. Therefore, we evaluated the risk factors and outcome of non- E. coli as uropathogens in patients with community-onset APN. Methods As a part of a nationwide multicentre surveillance study conducted in Korea, a total of 416 patients with CO- APN were collected with their epidemiological, antibiotic treatment and outcome data. Results The risk factors and outcomes of non- E. coli as uropathogens were evaluated in a total of 416 patients with culture-confirmed CO- APN. Non- E. coli caused 127 cases (30.5%) of CO- APN. CO- APN caused by non- E. coli resulted in higher inappropriate empirical therapy (38.6% vs. 20.1%, p < 0.001), longer hospital stay (12.6 days vs. 6.7 days, p = 0.005) and higher 30-day mortality (9.4% vs. 3.8% p = 0.020) compared with CO- APN caused by E. coli. Multivariate analyses showed that male gender ( OR, 3.48; CI, 2.13-5.67; p < 0.001), underlying haematological disease ( OR, 5.32; CI, 1.17-24.254; p = 0.031), underlying benign prostate hyperplasia ( OR, 2.61; CI, 1.02-6.74; p = 0.046), chronic indwelling urethral catheter ( OR, 6.34; CI, 1.26-31.84; p = 0.025) and admission history in the previous 6 months ( OR, 2.12; CI, 1.23-3.58; p = 0.005) were predictors for CO- APN caused by a non- E. coli isolate. Conclusions Community-onset APN caused by non- E. coli represents a distinct subset of urinary tract infections with worse outcomes. The defined risk factors related with non- E. coli should be taken into consideration when empirical antibiotic therapy is prescribed in patients with community-onset APN.
- Publication
International Journal of Clinical Practice, 2014, Vol 68, Issue 6, p749
- ISSN
1368-5031
- Publication type
Article
- DOI
10.1111/ijcp.12368