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- Title
A Clinicopathological Categorization System for Clinical Research in Coccidioidomycosis.
- Authors
Krogstad, Paul; Thompson, George R; Heidari, Arash; Kuran, Rasha; Stephens, Alexis V; Butte, Manish J; Johnson, Royce
- Abstract
A wide array of clinical manifestations follow infection with Coccidioides immitis or Coccidioides posadasii , ranging from asymptomatic infection to life-threatening pulmonary disease or extrapulmonary dissemination and meningitis. Epidemiological studies require consistent definitions of cases and their comparative clinical features. Understanding host and pathogen determinants of the severity of coccidioidomycosis also requires that specific clinical features (such as coccidioidal meningitis) and their overlap be precisely defined and quantified. Here we propose a system for categorization of outcomes of coccidioidomycosis in individuals who are not overtly immunocompromised that harmonizes clinical assessments during translational research of this increasingly common disease.
- Subjects
COCCIDIOIDOMYCOSIS; MEDICAL research; CLINICAL pathology; SYMPTOMS; LUNG diseases
- Publication
Open Forum Infectious Diseases, 2023, Vol 10, Issue 12, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofad597