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- Title
Glutaminin Travmatik Oral Mukozal Lezyonların İyileşmesi Üzerine Etkileri; Deneysel Çalışma.
- Authors
Akbaş, Sedat; Karabulut, Enes; Bozkurt, Ayşe Pervin Sutas; Aydın, Övgü; Düzgün, Dilek Ergün; Güngör, Gürcan
- Abstract
Objective: Glutamine (GLN) has an important function in regulation of acid-base balance, protein turnover, ammonia metabolism, catabolic situations and enhancing immune system. Prevention, treatment and care of oral mucosa lesions are very important for causing too many kinds of clinical and economic problem. In this experimental study, we aimed to reveal positive and different effects of GLN on traumatic oral mucosal lesions by using topical or systemic (enteral, parenteral) route. Methods: Twenty-one Wistar Albino rats were included to this experimental study and divided into 4 groups. Traumatic oral mucosal lesions were created to all rats after intraperitoneal administration of anesthesia. In control group; lesions were performed and no treatment was applied. In study groups; GLN treatment was applied by parenteral, enteral and topical routes. Healing of the lesions were observed macroscopically by high resolution photographs. Rats were sacrificed and biopsies were taken for histopathological and biochemical evaluations. Results: Histopathological evaluations of the biopsies; there was a significant difference between control and parenteral/topical groups for acute inflammation, control and parenteral groups for epithelial proliferation, control and topical groups for fibrosis. For biochemical evaluations; only malonildialdehyde levels have a significant difference between control and enteral groups (p<0.02). Conclusion: We observed a positive effect of GLN supplementation for the treatment of traumatic oral mucosal lesions. GLN administration by parenteral route had better results compared to the topical and enteral route. We therefore concluded that GLN supplements administered by topical or enteral route were a better alternative on traumatic oral mucosal lesions.
- Subjects
GLUTAMINE; ORAL mucosa diseases
- Publication
Journal of Academic Research in Medicine, 2018, Vol 8, Issue 3, p1
- ISSN
2146-6505
- Publication type
Article
- DOI
10.5152/jarem.2018.2008