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- Title
Possible mechanisms of fullerene C 60 antioxidant action.
- Authors
Chistyakov, V A; Smirnova, Yu O; Prazdnova, E V; Soldatov, A V
- Abstract
Novel mechanism of antioxidant activity of buckminsterfullerene C¿¿ based on protons absorbing and mild uncoupling of mitochondrial respiration and phosphorylation was postulated. In the present study we confirm this hypothesis using computer modeling based on Density Functional Theory. Fullerene's geroprotective activity is sufficiently higher than those of the most powerful reactive oxygen species scavengers. We propose here that C¿¿ has an ability to acquire positive charge by absorbing inside several protons and this complex could penetrate into mitochondria. Such a process allows for mild uncoupling of respiration and phosphorylation. This, in turn, leads to the decrease in ROS production.
- Publication
BioMed Research International, 2013, Vol 2013, p821498
- ISSN
2314-6133
- Publication type
Journal Article
- DOI
2013/821498