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- Title
Contact allergy to the active ingredients of Kathon® CG.
- Authors
Bruze, Magnus; Dahlquist, Inger; Fregert, Sigfrid; Gruvberger, Birgitta; Persson, Karin
- Abstract
The preservative Kathon[supx] CG is a commercial preparation, consisting of 2 active ingredients and other components. 28 patients with contact allergy to Kathon CG participated in a study in which patch testing was performed with serial dilutions, and with 5 chromatographically separated fractions. All reacted to fraction IV, and 2 patients also to fraction II. Mass spectrometry and nuclear magnetic resonance spectrometry identified fraction II and IV to be the active ingredients: 2-methyl-4-isothia-zolin-3-one and 5-chloro-2-methyl-4-isothiazolin-3-one.
- Subjects
SKIN inflammation; CONTACT dermatitis; ALLERGIES; SKIN tests; MASS spectrometry; CHROMATOGRAPHIC analysis
- Publication
Contact Dermatitis (01051873), 1987, Vol 16, Issue 4, p183
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1111/j.1600-0536.1987.tb01421.x