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- Title
The Influence of Intraperitoneal Transplantation of Free and Encapsulated Langerhans Islets on the Second Set Phenomenon.
- Authors
Orlowski, Tadeusz; Godlewska, Ewa; Mościcka, Maria; Sitarek, Elżbieta
- Abstract
To protect the allografts or xenografts against transplant rejection special semipermeable membranes are applied. So far, there are only a few studies on the influence of an immunoisolated graft on the recipient immune system. Therefore, the possibility that an intraperitoneally grafted alginate/poly L-lysine/alginate (APA) coated pancreatic islets graft can effectively sensitize the recipient and provoke second set phenomenon was studied. C3H male mice and male WAG rats were used as donors of full-thickness skin and of free or encapsulated islet intraperitoneal grafts. Male BALB/c mice served as recipients. Skin grafts were performed following the method of Billingham and Medawar. The length of the second skin graft survival time served as the criterion for the sensitizing capacity of the primary graft. APA encapsulation of islets delayed but has not prevented the development of the second set phenomenon. However, the second skin graft rejection time was significantly longer after grafting of encapsulated islets than after free islets transplantation. APA microencapsulation of intraperitoneally transplanted islets delayed but did not prevent the development of the second set phenomenon. Encapsulation does not ensure complete immunoisolation, but only creates “an artificially immunoprivileged site of transplantation.”
- Subjects
ISLANDS of Langerhans transplantation; TRANSPLANTATION of organs, tissues, etc.; SKIN grafting; ALGINATES; PEDICLE flaps (Surgery); ARTIFICIAL organs
- Publication
Artificial Organs, 2003, Vol 27, Issue 12, p1062
- ISSN
0160-564X
- Publication type
Article
- DOI
10.1111/j.1525-1594.2003.07046.x