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- Title
Synthesis and Antibacterial Activity of N-(un)substituted-N-((3,4-Methylenedioxyphenyl)methyl)arylsulfonamides.
- Authors
Aziz-ur-Rehman; Siddiqa, A.; Abbasi, M. A.; Rasool, S.; Nafeesa, K.; Gul, S.; Ahmed, I.; Afzal, S.
- Abstract
Sulfonamides belong to an active group with biological activities and these activities can be enhanced by introducing heterocyclic moiety. N-((3,4-methylenedioxyphenyl)methyl) arylsulfonamides (3a-f) were synthesized by gearing up (3,4-methylenedioxyphenyl)methyl amine (1) and arylsulfonyl chlorides (2a-f) in a weak basic aqueous medium. The target molecules, 6a-f and 7a-f were yielded by the reaction of 3a-f with ethyl iodide (4) and 4-flourobenzyl chloride (5) respectively in a weak basic aprotic polar medium. Structural analysis of the synthesized molecules was processed through the spectral data of IR, ¹H-NMR, 13C-NMR and EIMS. All the synthesized molecules were evaluated for the antibacterial activity and remained moderately better inhibitors
- Subjects
ANTIBACTERIAL agents; SULFONAMIDES; ORGANIC synthesis; BIOACTIVE compounds; ENZYME inhibitors; NUCLEAR magnetic resonance spectroscopy; CHLORIDES; HETEROCYCLIC compounds
- Publication
Pakistan Journal of Chemistry, 2013, Vol 3, Issue 4, p1
- ISSN
2220-2625
- Publication type
Article
- DOI
10.15228/2013.v03.i04.p01