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- Title
Enterovirus 71 2C Protein Inhibits NF-κB Activation by Binding to RelA(p65).
- Authors
Du, Haiwei; Yin, Peiqi; Yang, Xiaojie; Zhang, Leiliang; Jin, Qi; Zhu, Guofeng
- Abstract
Viruses evolve multiple ways to interfere with NF-κB signaling, a key regulator of innate and adaptive immunity. Enterovirus 71 (EV71) is one of primary pathogens that cause hand-foot-mouth disease. Here, we identify RelA(p65) as a novel binding partner for EV71 2C protein from yeast two-hybrid screen. By interaction with IPT domain of p65, 2C reduces the formation of heterodimer p65/p50, the predominant form of NF-κB. We also show that picornavirus 2C family proteins inhibit NF-κB activation and associate with p65 and IKKβ. Our findings provide a novel mechanism how EV71 antagonizes innate immunity.
- Subjects
VIRAL proteins; ENTEROVIRUSES; NF-kappa B; PROTEIN binding; NATURAL immunity
- Publication
Scientific Reports, 2015, p14302
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep14302