We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective.
- Authors
He, Quanguo; Liu, Jun; Liang, Jing; Liu, Xiaopeng; Li, Wen; Liu, Zhi; Ding, Ziyu; Tuo, Du
- Abstract
The blood–brain barrier (BBB) is a critical biological structure that prevents damage to the brain and maintains its bathing microenvironment. However, this barrier is also the obstacle to deliver beneficial drugs to treat CNS (central nervous system) diseases. Many efforts have been made for improvement of delivering drugs across the BBB in recent years to treat CNS diseases. In this review, the anatomical and functional structure of the BBB is comprehensively discussed. The mechanisms of BBB penetration are summarized, and the methods and effects on increasing BBB permeability are investigated in detail. It also elaborates on the physical, chemical, biological and nanocarrier aspects to improve drug delivery penetration to the brain and introduces some specific drug delivery effects on BBB permeability.
- Subjects
BLOOD-brain barrier; CENTRAL nervous system; BRAIN injuries; DRUG delivery systems; PERMEABILITY
- Publication
Cells (2073-4409), 2018, Vol 7, Issue 4, p24
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells7040024