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- Title
Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis.
- Authors
Paribello, Pasquale; Squassina, Alessio; Pisanu, Claudia; Meloni, Anna; Dall'Acqua, Stefano; Sut, Stefania; Nasini, Sofia; Bertazzo, Antonella; Congiu, Donatella; Garzilli, Mario; Guiso, Beatrice; Suprani, Federico; Pulcinelli, Vittoria; Iaselli, Maria Novella; Pinna, Ilaria; Somaini, Giulia; Arru, Laura; Corrias, Carolina; Pinna, Federica; Carpiniello, Bernardo
- Abstract
Background and Objectives: Alterations in hot cognition and in the tryptophan metabolism through serotonin (5-HT) and kynurenine (KYN) pathways have been associated with an increased risk of suicidal behavior. Here, we aim at probing the association between Stroop test performances and tryptophan pathway components in a sample of individuals with bipolar disorder (BD). Materials and Methods: We explored the association between the Emotion Inhibition Subtask (EIS) performances of the Brief Assessment of Cognition for Affective Disorders (BAC-A) and plasmatic levels of 5-hydroxytriptophan (5-HTP), 5-HT, KYN, 3-hydroxykynurenine (3-HK), quinolinic acid (QA), and kynurenic acid (KYNA) among subjects reporting lifetime suicide ideation (LSI) vs. non-LSI and subjects reporting lifetime suicide attempts (LSA) vs. non-LSA. Results: In a sample of 45 subjects with BD, we found a statistically significant different performance for LSA vs. non-LSA in the color naming (CN) and neutral words (NW) EIS subtasks. There was a significant association between CN performances and plasma 5-HTP levels among LSI and LSA subjects but not among non-LSI or non-LSA. Conclusions: In our sample, patients with LSA and LSI presented lower performances on some EIS subtasks compared to non-LSA and non-LSI. Moreover, we found an inverse correlation between plasma 5-HTP concentration and some EIS performances in LSA and LSI but not among non-LSA or non-LSI. This may represent an interesting avenue for future studies probing this complex association.
- Subjects
SUICIDAL behavior; BIPOLAR disorder; TRYPTOPHAN; QUINOLINIC acid; SECONDARY analysis
- Publication
Brain Sciences (2076-3425), 2023, Vol 13, Issue 4, p693
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci13040693