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- Title
Brain-to-BAT - and Back?: Crosstalk between the Central Nervous System and Thermogenic Adipose Tissue in Development and Therapy of Obesity.
- Authors
Till, Andreas; Fries, Charlotte; Fenske, Wiebke K.
- Abstract
The body of mammals harbors two distinct types of adipose tissue: while cells within the white adipose tissue (WAT) store surplus energy as lipids, brown adipose tissue (BAT) is nowadays recognized as the main tissue for transforming chemical energy into heat. This process, referred to as 'non-shivering thermogenesis', is facilitated by the uncoupling of the electron transport across mitochondrial membranes from ATP production. BAT-dependent thermogenesis acts as a safeguarding mechanism under reduced ambient temperature but also plays a critical role in metabolic and energy homeostasis in health and disease. In this review, we summarize the evolutionary structure, function and regulation of the BAT organ under neuronal and hormonal control and discuss its mutual interaction with the central nervous system. We conclude by conceptualizing how better understanding the multifaceted communicative links between the brain and BAT opens avenues for novel therapeutic approaches to treat obesity and related metabolic disorders.
- Subjects
CENTRAL nervous system; ADIPOSE tissues; WHITE adipose tissue; BROWN adipose tissue; MITOCHONDRIAL membranes
- Publication
Brain Sciences (2076-3425), 2022, Vol 12, Issue 12, p1646
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci12121646