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- Title
FC-55 Efficacy of low-dose immunotherapy in the treatment of canine atopic dermatitis: a prospective, double-blinded study.
- Authors
Colombo, S.; Hill, P. B.; Shaw, D. J.; Thoday, K. L.
- Abstract
There are anecdotal reports of increased effectiveness of allergen-specific immunotherapy (ASIT) with doses of vaccine lower than that recommended by the manufacturers. However, no controlled studies have been carried out. The aim of this prospective, double-blinded study was to evaluate whether induction and maintenance with low-dose (LD) ASIT resulted in a different success rate compared with the standard dose (SD). Twenty-seven dogs with confirmed atopic dermatitis were allotted by block randomisation to two groups. One ( n = 13) received SD ASIT; the other ( n = 14) received LD ASIT (1/10 of the SD) following the same frequency protocol. Cases were graded at 0, 3, 6 and 9 months for clinical signs using a modified Canine Atopic Dermatitis Extent and Severity Index (mCADESI) and for pruritus using a 0–5 descriptor scale. There were no significant differences between the groups in the pruritus and mCADESI scores ( P > 0.155) at the end of the study. Changes in pruritus ( P > 0.920) and mCADESI ( P > 0.296) scores from the beginning to the end of the study were similar in both groups, with pruritus scores in both groups not changing during the study ( P > 0.052). However, significant reductions in mCADESI scores were seen in both groups ( P < 0.032). Six dogs achieved a final pruritus score of 0, six dogs achieved a reduction in pruritus score, and 15 did not improve or worsened. There was, therefore, no evidence that LD ASIT was more effective than the standard protocol. Funding: Petsavers, British Small Animal Veterinary Association, Wellcome Trust.
- Subjects
ALLERGENS; IMMUNOTHERAPY; THERAPEUTICS; ITCHING; ATOPIC dermatitis; RESEARCH; DOGS
- Publication
Veterinary Dermatology, 2004, Vol 15, p38
- ISSN
0959-4493
- Publication type
Abstract
- DOI
10.1111/j.1365-3164.2004.411_55.x