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- Title
Antitumor effects of fecal microbiota transplantation: Implications for microbiome modulation in cancer treatment.
- Authors
Hui Xu; Chenxi Cao; Yuqing Ren; Siyuan Weng; Long Liu; Chunguang Guo; Libo Wang; Xinwei Han; Jianzhuang Ren; Zaoqu Liu
- Abstract
Fecal microbiome transplantation (FMT) from healthy donors is one of the techniques for restoration of the dysbiotic gut, which is increasingly being used to treat various diseases. Notably, mountingevidence inrecent years revealed thatFMT has made a breakthrough in the oncology treatment area, especially by improving immunotherapy efficacy to achieve antitumor effects. However, themechanism of FMT in enhancing antitumor effectsof immune checkpoint blockers (ICBs) has not yet been fully elucidated. This review systematically summarizes the role of microbes and their metabolites in the regulation of tumor immunity. We highlight themechanism of action of FMT in the treatment of refractory tumors as well as in improving the efficacy of immunotherapy. Furthermore, we summarize ongoing clinical trials combining FMT with immunotherapy and further focus on refined protocols for the practice of FMT in cancer treatment, which could guide future directions and priorities of FMT scientific development.
- Subjects
FECAL microbiota transplantation; CANCER treatment; IMMUNOREGULATION; IMMUNE checkpoint proteins; TUMOR treatment
- Publication
Frontiers in Immunology, 2022, Vol 13, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2022.949490