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- Title
No effects of a 6‐week intervention with a glucagon‐like peptide‐1 receptor agonist on pancreatic volume and oedema in obese men without diabetes.
- Authors
Svane, Maria S.; Johannesen, Helle H.; Martinussen, Christoffer; Bojsen‐Møller, Kirstine N.; Hansen, Martin Lundsgaard; Hansen, Adam E.; Deacon, Carolyn F.; Hartmann, Bolette; Keller, Sune H.; Klausen, Thomas L.; Loft, Annika; Kjaer, Andreas; Madsbad, Sten; Löfgren, Johan; Holst, Jens J.; Wewer Albrechtsen, Nicolai J.
- Abstract
Aim: To investigate the effect of a glucagon‐like peptide‐1 receptor agonist (GLP‐1RA), liraglutide, on pancreatic volume, oedema, cellularity and DNA synthesis in humans. Materials and Methods: We performed an open‐label study in 14 obese men (age 38 ± 11 years, body mass index 32 ± 4 kg/m2) without diabetes. Subjects were examined at baseline, during titration (week 4) of liraglutide towards 3.0 mg/day, and 2 weeks after steady‐state treatment (week 6) of a final dose of liraglutide. The primary endpoint was pancreatic volume determined by magnetic resonance imaging. Secondary endpoints included pancreatic oedema and cellularity, positron emission tomography‐based [18F]fluorothymidine (FLT) uptake (DNA synthesis) and plasma pancreatic enzymes. Results: Plasma amylase (+7 U/L [95% confidence intervals 3‐11], P <.01) and lipase (+19 U/L [7‐30], P <.01) increased during liraglutide treatment. Pancreatic volume did not change from baseline to steady state of treatment (+0.2 cm3 [−8‐8], P =.96) and no change in pancreatic cellular infiltration was found (P =.22). During titration of liraglutide, FLT uptake in pancreatic tissue increased numerically (+0.08 [0.00‐0.17], P =.0507). Conclusions: Six weeks of treatment with liraglutide did not affect pancreatic volume, oedema or cellularity in obese men without diabetes.
- Subjects
GLUCAGON-like peptide-1 agonists; PANCREATIC enzymes; GLUCAGON-like peptide-1 receptor; DNA synthesis; EDEMA; BODY mass index; OBESITY
- Publication
Diabetes, Obesity & Metabolism, 2020, Vol 22, Issue 10, p1837
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.14106