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- Title
Facile synthesis of multifunctional nanocomposites with good compatibility for efficient dual-mode T<sub>1</sub> and T<sub>2</sub> magnetic resonance imaging and gene delivery.
- Authors
Xiang, Hui-Hui; Song, Meng-Meng; Fei, Meng-Yu; Wang, Run-Jie; Tao, Xiao-Fang; Shen, Yu-Xian; Yu, Yong-Qiang
- Abstract
Nanostructure-based materials for multimodal imaging have attracted great attentions. Here we report a new formulation integrated gadolinium (Gd) and magnetite (Fe3O4) nanoparticles as magnetic resonance (MR) imaging contrast agent at both T1 mode and T2 mode. Polyetherimide coated iron oxide (Fe3O4@PEI) nanoparticles were first synthesized and then conjugated to diethylenetriamine pentaacetic acid (DTPA), which further chelated with Gd3+ ions (Fe3O4@PEI@DTPA-Gd). Both phantom and MR studies showed Fe3O4@PEI@DTPA-Gd nanocomposites could be applied in two modes (r1 = 4.7 mM−1 s−1, r2 = 131.82 mM−1 s−1). MTT and fluorescent staining results also suggested that the nanocomposites had good biocompatibility. Besides, Fe3O4@PEI@DTPA-Gd nanocomposites exhibited high entrap efficiency when the mass ratio of nanocomposites to DNA was up to 30:1. The in vitro gene transfection ability was also evidenced. Therefore, Fe3O4@PEI@DTPA-Gd nanocomposites can be employed as a potential candidate for MRI guided clinical diagnosis and gene delivery guided therapy.
- Subjects
GADOLINIUM; MAGNETIC resonance imaging; GENE transfection; FERRIC oxide; MAGNETIC nanoparticles; MAGNETIC resonance
- Publication
Applied Nanoscience, 2019, Vol 9, Issue 8, p2019
- ISSN
2190-5509
- Publication type
Article
- DOI
10.1007/s13204-019-01042-0