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- Title
Ambulatory blood pressure parameters and their association with albuminuria in adolescents with type 1 diabetes mellitus.
- Authors
Sołtysiak, Jolanta; Skowrońska, Bogda; Maćkowiak-Lewandowicz, Katarzyna; Blumczyński, Andrzej; Elżbieta, Kaczmarek; Ostalska-Nowicka, Danuta; Zachwieja, Jacek
- Abstract
Background: This study aimed to evaluate the blood pressure (BP) status, including arterial stiffness parameters, hemodynamic indicators, circadian profile, and its association with albuminuria in adolescents with type 1 diabetes mellitus (DM1). Methods: The analysis included 46 patients, with diabetes duration of 7.38 ± 3.48 years. Ambulatory blood pressure monitoring (ABPM) was conducted using an oscillometric device, the Mobil-O-Graph, which is a Pulse Wave Analysis Monitor. Results: Hypertension (HT) was diagnosed in 31 adolescents (67% of patients), primarily due to isolated nocturnal BP (21 cases, 68% of HT cases). The HT group exhibited significantly increased diastolic load (DL). Pulse wave velocity (PWV, a measure of arterial stiffness) values showed a strong correlation with both peripheral systolic BP (r = 0.954) and central systolic BP (r = 0.838). Additionally, non-dipping status was found in 61% of the HT group. Urinary albumin excretion (UAE) was positively correlated with diastolic BP (particularly nocturnal) peripheral and central BP, DL, heart rate, augmentation index (AIx@75), and nocturnal total vascular resistance (TVR). Diastolic non-dippers exhibited a significant increase in UAE. Conclusions: Hypertension is a common complication in adolescents with type 1 diabetes mellitus, primarily caused by elevated nocturnal diastolic BP. Albuminuria is mainly associated with diastolic BP, especially during the nocturnal period and in cases of diastolic non-dipping status. The association of UAE with AIx@75 and nocturnal TVR suggests the presence of early-stage vascular disease in diabetic adolescents.
- Subjects
HYPERTENSION risk factors; TYPE 1 diabetes; RISK assessment; STATISTICAL correlation; ALBUMINURIA; ARTERIAL diseases; HEART rate monitoring; DIABETIC nephropathies; HEMODYNAMICS; VASCULAR resistance; CIRCADIAN rhythms; RESEARCH; DIASTOLIC blood pressure; AMBULATORY blood pressure monitoring; PULSE wave analysis; ALBUMINS; TIME; COMORBIDITY; DISEASE risk factors; ADOLESCENCE
- Publication
Pediatric Nephrology, 2024, Vol 39, Issue 10, p3037
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-024-06416-3