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- Title
Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397.
- Authors
Tzeng-Horn Leu; Ming-Chei Maa
- Abstract
Presents a study that demonstrated that both focal adhesion kinase (FAK) tyrosine (Tyr)-576/577 and Tyr-863 phosphorylation regulated FAK Tyr-397 phosphorylation during in vitro FAK immunocomplex kinase experiments. Increase in the intermolecular transphosphorylation activity of FAK; Reduction of the complex formation between standard reference compound and 3F-FAK; Regulation of cis- and transphosphorylation activities of FAK by a differential tyrosyl phosphorylation mechanism.
- Subjects
PROTEIN-tyrosine kinases; PHOSPHORYLATION; PHOSPHORYLASES
- Publication
Oncogene, 2002, Vol 21, Issue 46, p6992
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1205904