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- Title
Crystal ball gazing: new therapeutic targets for hyperuricaemia and gout.
- Authors
N. Dalbeth; T. Merriman
- Abstract
Recent studies in diverse disciplines have led to significant advances in the understanding of the basic biology of hyperuricaemia and gout, with important implications for future treatment. These findings include genetic variation within SLC2A9 as a key regulator of urate homeostasis, and identification of urate—anion exchanger urate transporter 1 (URAT1) and other renal uric acid transporters. Recognition of urate as an endogenous danger signal and activator of the adaptive immune response suggests an important role for urate crystals in non-microbial immune surveillance. The central role of NALP3 inflammasome activation and IL-1β signalling in the initiation of the acute gout attack raises the possibility of new therapeutic targets. Disordered osteoclastogenesis in patients with chronic gout highlights potential therapies for prevention of joint damage. This review summarizes these findings and the potential relevance for future management of gout.
- Subjects
CRYSTAL gazing; HYPERURICEMIA; GOUT treatment; TARGETED drug delivery; HUMAN genetic variation; IMMUNE response; JOINT injuries; BIOLOGICAL transport; PREVENTION; THERAPEUTICS
- Publication
Rheumatology, 2009, Vol 48, Issue 3, p222
- ISSN
1462-0324
- Publication type
Article