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- Title
Novel Methods for Clinical Risk Stratification in Patients with Colorectal Liver Metastases.
- Authors
Ki-Yeol Kim; Nam Kyu Kim; In-Ho Cha; Joong Bae Ahn; Jin Sub Choi; Gi-Hong Choi; Joon Suk Lim; Kang Young Lee; Seung Hyuk Baik; Byung Soh Min; Hyuk Hur; Jae Kyung Roh; Sang Joon Shin
- Abstract
Purpose Colorectal cancer patients with liver-confined metastases are classified as stage IV, but their prognoses can differ from metastases at other sites. In this study, we suggest a novel method for risk stratification using clinically effective factors. Materials and Methods Data on 566 consecutive patients with colorectal liver metastasis (CLM) between 1989 and 2010 were analyzed. This analysis was based on principal component analysis (PCA). Results The survival rate was affected by carcinoembryonic antigen (CEA) level (p < 0.001; risk ratio, 1.90), distribution of liver metastasis (p=0.014; risk ratio, 1.46), and disease-free interval (DFI; p < 0.001; risk ratio, 1.98). When patients were divided into three groups according to PCA score using significantly affected factors, they showed significantly different survival patterns (p < 0.001). Conclusion The PCA scoring system based on CEA level, distribution of liver metastasis, and DFI may be useful for preoperatively determining prognoses in order to assist in clinical decisionmaking and designing future clinical trials for CLM treatment.
- Subjects
COLON cancer diagnosis; RISK of metastasis; CANCER risk factors; LIVER cancer; MULTIPLE correspondence analysis (Statistics); PRINCIPAL components analysis; CARCINOEMBRYONIC antigen
- Publication
Cancer Research & Treatment, 2015, Vol 47, Issue 2, p242
- ISSN
1598-2998
- Publication type
Article
- DOI
10.4143/crt.2014.066