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- Title
Effect of Once-Daily Alfuzosin on Urinary Symptoms and Flow Rate in Benign Prostatic Hyperplasia: A 24-Hour Home-Uroflowmetry Evaluation.
- Authors
De Nunzio, Cosimo; Franco, Giorgio; Leonardo, Costantino; Trucchi, Alberto; Tubaro, Andrea; Laurenti, Cesare
- Abstract
Objective: To analyse the clinical and 24-hour urinary flow efficacy of alfuzosin 10mg once daily (OD), by means of the International Prostate Symptom Score (I-PSS) and home-based uroflowmetry (P-Flow) measurement, in patients with lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia. Materials and methods: In this open-label trial, 12 male patients (median age 67 years) with an I-PSS >15 (median 16) and maximum urinary flow (Qmax) <15 mL/sec were evaluated. Patients underwent two days of P-Flow evaluation, and then received alfuzosin 10mg OD from day 3 to day 9. On days 7 and 8 they underwent further P-Flow evaluation. A second post-baseline evaluation I-PSS was recorded on day 9. Results: Overall, 328 urinary flows were recorded and evaluated, an average of 27 flows per patient. A statistically significant improvement in mean maximum flow: (Qmax) [10.8 ± 2.8 vs 12.4 ± 3 mL/sec; p = 0.02] and urinary voiding volume (219 ± 70 vs 233 ± 55mL; p = 0.04) were observed after treatment compared with baseline. No differences in the number of urinary flows were observed between baseline and after treatment (13 ± 2.9 vs 14 ± 1.8 flows; p = 0.199). A statistically significant difference between the two evaluations was noted for I-PSS (15.7 ± 0.8 and 9.5 ± 2; p = 0.02). Mean Qmax recorded during treatment was always higher than baseline at different daytime evaluations. Conclusion: The alfuzosin 10mg OD formulation showed a significant improvement in I-PSS as well as a significant improvement in urinary flow parameters (Qmax and urinary voiding volume) lasting for 24 hours in patients with LUTS.
- Subjects
PROSTATE hypertrophy; PATIENTS; SYMPTOMS; STATISTICS; HYPERPLASIA; CLINICAL trials
- Publication
Clinical Drug Investigation, 2005, Vol 25, Issue 6, p359
- ISSN
1173-2563
- Publication type
Article
- DOI
10.2165/00044011-200525060-00001