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- Title
A novel role for placental leucine aminopeptidase (P-LAP) as a determinant of chemoresistance in endometrial carcinoma cells.
- Authors
Kondo, Chihiro; Shibata, Kiyosumi; Terauchi, Mikio; Kajiyama, Hiroaki; Ino, Kazuhiko; Nomura, Seiji; Nawa, Akihiro; Mizutani, Shigehiko; Kikkawa, Fumitaka
- Abstract
In several recent studies, we have shown that P-LAP can be a poor prognostic factor and a factor of chemoresistance in endometrial carcinoma, especially in the advanced patients. In our study, we investigated whether P-LAP alters the expression of apoptosis regulatory proteins as a mechanism of drug resistance. We transfected P-LAP cDNA into A-MEC cells (endometrial adenocarcinoma cell line), and A-MEC-LAP cells displayed a 1.8-fold, 2.0-fold and 1.7-fold increase in IC
- Publication
International Journal of Cancer, 2006, Vol 118, Issue 6, p1390
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.21509