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Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites.
Published in:
PLoS Pathogens, 2024, v. 20, n. 6, p. 1, doi. 10.1371/journal.ppat.1012360
By:
- Koussis, Konstantinos;
- Haase, Silvia;
- Withers-Martinez, Chrislaine;
- Flynn, Helen R.;
- Kunzelmann, Simone;
- Christodoulou, Evangelos;
- Ibrahim, Fairouz;
- Skehel, Mark;
- Baker, David A.;
- Blackman, Michael J.
Publication type:
Article
Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery.
Published in:
PLoS Biology, 2019, v. 17, n. 5, p. 1, doi. 10.1371/journal.pbio.3000264
By:
- Patel, Avnish;
- Perrin, Abigail J.;
- Flynn, Helen R.;
- Bisson, Claudine;
- Withers-Martinez, Chrislaine;
- Treeck, Moritz;
- Flueck, Christian;
- Nicastro, Giuseppe;
- Martin, Stephen R.;
- Ramos, Andres;
- Gilberger, Tim W.;
- Snijders, Ambrosius P.;
- Blackman, Michael J.;
- Baker, David A.
Publication type:
Article
TLR and TNF-R1 activation of the MKK3/MKK6-p38a axis in macrophages is mediated by TPL-2 kinase.
Published in:
Biochemical Journal, 2016, v. 473, n. 18, p. 2845, doi. 10.1042/BCJ20160502
By:
- Pattison, Michael J.;
- Mitchell, Olivia;
- Flynn, Helen R.;
- Chao-Sheng Chen;
- Huei-Ting Yang;
- Ben-Addi, Hakem;
- Boeing, Stefan;
- Snijders, Ambrosius P.;
- Ley, Steven C.
Publication type:
Article
Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme.
Published in:
eLife, 2020, p. 1, doi. 10.7554/eLife.61509
By:
- Fedoryshchak, Roman O.;
- Přechová, Magdalena;
- Butler, Abbey M.;
- Lee, Rebecca;
- O'Reilly, Nicola;
- Flynn, Helen R.;
- Snijders, Ambrosius P.;
- Eder, Noreen;
- Ultanir, Sila;
- Mouilleron, Stephane;
- Treisman, Richard
Publication type:
Article
Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity.
Published in:
eLife, 2016, p. 1, doi. 10.7554/eLife.15460
By:
- Panayiotou, Richard;
- Miralles, Francesc;
- Pawlowski, Rafal;
- Diring, Jessica;
- Flynn, Helen R.;
- Skehel, Mark;
- Treisman, Richard
Publication type:
Article
TPL‐2 kinase induces phagosome acidification to promote macrophage killing of bacteria.
Published in:
EMBO Journal, 2021, v. 40, n. 10, p. 1, doi. 10.15252/embj.2020106188
By:
- Breyer, Felix;
- Härtlova, Anetta;
- Thurston, Teresa;
- Flynn, Helen R;
- Chakravarty, Probir;
- Janzen, Julia;
- Peltier, Julien;
- Heunis, Tiaan;
- Snijders, Ambrosius P;
- Trost, Matthias;
- Ley, Steven C
Publication type:
Article
The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41304-8
By:
- Mihaylov, Simeon R.;
- Castelli, Lydia M.;
- Lin, Ya-Hui;
- Gül, Aytac;
- Soni, Nikita;
- Hastings, Christopher;
- Flynn, Helen R.;
- Păun, Oana;
- Dickman, Mark J.;
- Snijders, Ambrosius P.;
- Goldstone, Robert;
- Bandmann, Oliver;
- Shelkovnikova, Tatyana A.;
- Mortiboys, Heather;
- Ultanir, Sila K.;
- Hautbergue, Guillaume M.
Publication type:
Article
Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics.
Published in:
EMBO Journal, 2018, v. 37, n. 24, p. N.PAG, doi. 10.15252/embj.201899763
By:
- Baltussen, Lucas L;
- Negraes, Priscilla D;
- Silvestre, Margaux;
- Claxton, Suzanne;
- Moeskops, Max;
- Christodoulou, Evangelos;
- Flynn, Helen R;
- Snijders, Ambrosius P;
- Muotri, Alysson R;
- Ultanir, Sila K
Publication type:
Article
Identification of Holliday junction resolvases from humans and yeast.
Published in:
Nature, 2008, v. 456, n. 7220, p. 357, doi. 10.1038/nature07470
By:
- Ip, Stephen C. Y.;
- Rass, Ulrich;
- Blanco, Miguel G.;
- Flynn, Helen R.;
- Skehel, J. Mark;
- West, Stephen C.
Publication type:
Article
Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.
Published in:
Life Science Alliance, 2023, v. 6, n. 2, p. 1, doi. 10.26508/lsa.202201712
By:
- Roşianu, Flavia;
- Mihaylov, Simeon R.;
- Eder, Noreen;
- Martiniuc, Antonie;
- Claxton, Suzanne;
- Flynn, Helen R.;
- Jalal, Shamsinar;
- Domart, Marie-Charlotte;
- Collinson, Lucy;
- Skehel, Mark;
- Snijders, Ambrosius P.;
- Krause, Matthias;
- Tooze, Sharon A.;
- Ultanir, Sila K.
Publication type:
Article
Juxtamembrane Shedding of Plasmodium falciparum AMA1 Is Sequence Independent and Essential, and Helps Evade Invasion-Inhibitory Antibodies.
Published in:
PLoS Pathogens, 2011, v. 7, n. 12, p. 1, doi. 10.1371/journal.ppat.1002448
By:
- Olivieri, Anna;
- Collins, Christine R.;
- Hackett, Fiona;
- Withers-Martinez, Chrislaine;
- Marshall, Joshua;
- Flynn, Helen R.;
- Skehel, J. Mark;
- Blackman, Michael J.
Publication type:
Article
Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders.
Published in:
Frontiers in Molecular Neuroscience, 2024, p. 01, doi. 10.3389/fnmol.2024.1359154
By:
- Jianzhi Jiang;
- Wilkinson, Brent;
- Flores, Ilse;
- Hartel, Nicolas;
- Mihaylov, Simeon R.;
- Clementel, Veronica A.;
- Flynn, Helen R.;
- Alkuraya, Fowsan S.;
- Ultanir, Sila;
- Graham, Nicholas A.;
- Coba, Marcelo P.
Publication type:
Article
Author Correction: YAP1/TAZ drives ependymoma-like tumour formation in mice.
Published in:
2020
By:
- Eder, Noreen;
- Roncaroli, Federico;
- Domart, Marie-Charlotte;
- Horswell, Stuart;
- Andreiuolo, Felipe;
- Flynn, Helen R.;
- Lopes, Andre T.;
- Claxton, Suzanne;
- Kilday, John-Paul;
- Collinson, Lucy;
- Mao, Jun-Hao;
- Pietsch, Torsten;
- Thompson, Barry;
- Snijders, Ambrosius P.;
- Ultanir, Sila K.
Publication type:
Correction Notice
YAP1/TAZ drives ependymoma-like tumour formation in mice.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16167-y
By:
- Eder, Noreen;
- Roncaroli, Federico;
- Dolmart, Marie-Charlotte;
- Horswell, Stuart;
- Andreiuolo, Felipe;
- Flynn, Helen R.;
- Lopes, Andre T.;
- Claxton, Suzanne;
- Kilday, John-Paul;
- Collinson, Lucy;
- Mao, Jun-Hao;
- Pietsch, Torsten;
- Thompson, Barry;
- Snijders, Ambrosius P.;
- Ultanir, Sila K.
Publication type:
Article
A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in calcium-induced Toxoplasma gondii egress.
Published in:
PLoS Pathogens, 2022, v. 18, n. 10, p. 1, doi. 10.1371/journal.ppat.1010901
By:
- Nofal, Stephanie D.;
- Dominicus, Caia;
- Broncel, Malgorzata;
- Katris, Nicholas J.;
- Flynn, Helen R.;
- Arrizabalaga, Gustavo;
- Botté, Cyrille Y.;
- Invergo, Brandon M.;
- Treeck, Moritz
Publication type:
Article

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