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- Title
Effectiveness of tomato extract on Super Oxide Dismutase (SOD) levels and Melasma Area Severity Index (MASI) in patients of melasma.
- Authors
Avianggi, Hayra Diah; Indar, Retno; Adriani, Diah; Puguh Riyanto; Muslimin; Kabulrachman
- Abstract
Background Melasma is present in 40% of cases in Southeast Asia. In Indonesia, the ratio of women and men is 24:1. Melasma causes a lot of social pressure. Treatment of melasma is a concern because it is often unresponsive to therapy with variable success rates and high recurrence rates. Lycopene-rich-tomato extract is needed to avoid oxidative stress due to UV rays that cause melasma through the melanogenesis pathway. Methods 62 subjects with melasma were recruited into a true-experimental-clinic with a doubleblind, randomized, pre and post-test control design over 12 weeks at the Diponegoro National Hospital, to receive either an oral tomato extract supplement or a placebo. All of the subjects applied topical sunscreen and hydroquinone-4%-cream. Subjects were assessed by superoxide dismutase (SOD) levels and Melasma area and Severity Index (MASI). Results 59 patients completed the research. Serum SOD levels in the tomato extract supplementation treatment group were higher than in the control group given the placebo, with Delta SOD (p<0.05). The difference in MASI scores after therapy in the treatment group had a significant decrease compared to the control group, with statistical review results suggesting that the difference was significant (p <0.05). Conclusion Supplementation of tomato extract as an adjuvant therapy can increase serum SOD levels and improve melasma severity.
- Subjects
SOUTHEAST Asia; INDONESIA; MELANOSIS; SUPEROXIDE dismutase; TOMATOES; ULTRAVIOLET radiation; SOCIAL pressure
- Publication
Journal of Pakistan Association of Dermatologists, 2021, Vol 31, Issue 4, p652
- ISSN
1560-9014
- Publication type
Article