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- Title
Astragalus Polysaccharide Modulates the Gut Microbiota and Metabolites of Patients with Type 2 Diabetes in an In Vitro Fermentation Model.
- Authors
Zhang, Xin; Jia, Lina; Ma, Qian; Zhang, Xiaoyuan; Chen, Mian; Liu, Fei; Zhang, Tongcun; Jia, Weiguo; Zhu, Liying; Qi, Wei; Wang, Nan
- Abstract
This study investigated the effect of astragalus polysaccharide (APS, an ingredient with hypoglycemic function in a traditional Chinese herbal medicine) on gut microbiota and metabolites of type 2 diabetes mellitus (T2DM) patients using a simulated fermentation model in vitro. The main components of APS were isolated, purified, and structure characterized. APS fermentation was found to increase the abundance of Lactobacillus and Bifidobacterium and decrease the Escherichia-Shigella level in the fecal microbiota of T2DM patients. Apart from increasing propionic acid, APS also caused an increase in all-trans-retinoic acid and thiamine (both have antioxidant properties), with their enrichment in the KEGG pathway associated with thiamine metabolism, etc. Notably, APS could also enhance fecal antioxidant properties. Correlation analysis confirmed a significant positive correlation of Lactobacillus with thiamine and DPPH-clearance rate, suggesting the antioxidant activity of APS was related to its ability to enrich some specific bacteria and upregulate their metabolites.
- Subjects
VITAMIN B1 metabolism; ANTIOXIDANT analysis; ASTRAGALUS (Plants); CHINESE medicine; IN vitro studies; BIFIDOBACTERIUM; PROTEINS; HIGH performance liquid chromatography; FECES; PROPIONIC acid; CARBOHYDRATES; DIGESTION; DATA analysis; RESEARCH funding; HERBAL medicine; GUT microbiome; SPECTROPHOTOMETERS; MONOSACCHARIDES; ENZYMES; DESCRIPTIVE statistics; POLYSACCHARIDES; PLANT extracts; METABOLITES; FERMENTATION; BIOTRANSFORMATION (Metabolism); RNA; TYPE 2 diabetes; LACTOBACILLUS; ESCHERICHIA; TRETINOIN; PHENOLS; ELECTROSPRAY ionization mass spectrometry; ONE-way analysis of variance; STATISTICS; METABOLOMICS; DATA analysis software; NONPARAMETRIC statistics
- Publication
Nutrients, 2024, Vol 16, Issue 11, p1698
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16111698