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- Title
Therapeutic Effects of Live Lactobacillus plantarum GKD7 in a Rat Model of Knee Osteoarthritis.
- Authors
Lin, Yen-You; Chang, Sunny Li-Yun; Liu, Shan-Chi; Achudhan, David; Tsai, You-Shan; Lin, Shih-Wei; Chen, Yen-Lien; Chen, Chin-Chu; Chang, Jun-Way; Fong, Yi-Chin; Hu, Sung-Lin; Tang, Chih-Hsin
- Abstract
Osteoarthritis (OA) is a painful, progressive chronic inflammatory disease marked by cartilage destruction. Certain synovial inflammatory cytokines, such as IL-1β and TNF-α, promote OA inflammation and pain. Lactobacillus spp. is a well-known probiotic with anti-inflammatory, analgesic, antioxidant, and antiosteoporotic properties. This study evaluated the therapeutic effects of a live L. plantarum strain (GKD7) in the anterior cruciate ligament transection (ACLT)-induced OA rat model. The results show that oral administration of live L. plantarum GKD7 improved weight-bearing asymmetry after ACLT surgery. Moreover, micro-computed tomography images and histopathological analysis show that oral live L. plantarum GKD7 improved subchondral bone architecture, protected articular cartilage against ACLT-induced damage, and reduced synovial inflammation. L. plantarum GKD7 also reduced IL-1β and TNF-α production in OA cartilage and synovium. Thus, orally administered live L. plantarum GKD7 appears to effectively slow the progression of OA.
- Subjects
THERAPEUTIC use of probiotics; KNEE osteoarthritis; BIOLOGICAL models; DISEASE progression; SYNOVIAL membranes; ANIMAL experimentation; ANTI-inflammatory agents; ANALGESICS; ORAL drug administration; ANTIOXIDANTS; INTERLEUKIN-1; PROBIOTICS; RATS; TREATMENT effectiveness; ANTERIOR cruciate ligament injuries; TUMOR necrosis factors; LACTOBACILLUS; COMPUTED tomography; ARTICULAR cartilage; DISEASE complications; EVALUATION
- Publication
Nutrients, 2022, Vol 14, Issue 15, p3170
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14153170