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- Title
Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV.
- Authors
Manzano, Mónica; Talavera-Rodríguez, Alba; Moreno, Elena; Madrid, Nadia; Gosalbes, María José; Ron, Raquel; Dronda, Fernando; Pérez-Molina, José A.; Lanza, Val F.; Díaz, Jorge; Moreno, Santiago; Navia, Beatriz; Serrano-Villar, Sergio
- Abstract
While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two types of dietary patterns were determined. We explored the associations of each dietary pattern with gut microbiota and plasma inflammatory biomarkers. Results: We appreciated two dietary patterns, Mediterranean-like (MEL) and one Western-like (WEL). Compared to participants with the WEL pattern, participants with MEL pattern showed higher abundance of Lachnospira (p-value = 0.02) and lower levels of the inflammatory biomarkers D-dimer (p-value = 0.050) and soluble TNF-alpha receptor 2 (sTNFR2) (p-value = 0.049). Men who have sex with men (MSM) with MEL pattern had lower abundance of Erysipelotrichaceae (p-value < 0.001) and lower levels of D-dimer (p-value = 0.026) than MSM with WEL pattern. Conclusion: MEL pattern favours Lachnospira abundance, and protects against Erysipelotrichaceae abundance and higher levels of the inflammatory biomarkers D-dimer and sTNFR2, precursors of inflammatory processes in HIV-infected patients. Our study contributes to understanding the determinants of a healthier diet and its connections with gut microbiota and inflammation.
- Subjects
INFLAMMATION prevention; HIV infection complications; MEDITERRANEAN diet; WESTERN diet; BIOMARKERS; HIV-positive persons; HIV infections; GUT microbiome; CROSS-sectional method; ANTIRETROVIRAL agents; CELL receptors; COMPARATIVE studies; SEX distribution; DESCRIPTIVE statistics; MEN who have sex with men; FIBRIN fibrinogen degradation products
- Publication
Nutrients, 2022, Vol 14, Issue 6, p1221
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14061221