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- Title
Anti-Fatigue Effect of a Dietary Supplement from the Fermented By-Products of Taiwan Tilapia Aquatic Waste and Monostroma nitidum Oligosaccharide Complex.
- Authors
Chen, Ying-Ju; Kuo, Chun-Yen; Kong, Zwe-Ling; Lai, Chin-Ying; Chen, Guan-Wen; Yang, An-Jen; Lin, Liang-Hung; Wang, Ming-Fu; Sakkas, Giorgos K.
- Abstract
The Taiwan Tilapia is an important aquaculture product in Taiwan. The aquatic by-products generated during Tilapia processing, such as fish bones and skin, are rich in minerals and protein. We aimed to explore the effect of a dietary supplement, comprising a mixture of fermented Tilapia by-products and Monostroma nitidum oligosaccharides as the raw materials, combined with physical training on exercise performance and fatigue. We used a mouse model that displays a phenotype of accelerated aging. Male senescence-accelerated mouse prone-8 (SAMP8) mice were divided into two control groups—with or without physical training—and supplemented with different doses (0.5 times: 412 mg/kg body weight (BW)/day; 1 time: 824 mg/kg BW/day; 2 times: 1648 mg/kg BW/day) of fermented Tilapia by-products and Monostroma nitidum oligosaccharide-containing mixture and combined with exercise training groups. Exercise performance was determined by testing forelimb grip strength and with a weight-bearing exhaustive swimming test. Animals were sacrificed to collect physical fatigue-related biomarkers. Mice dosed at 824 or 1648 mg/kg BW/day showed improvement in their exercise performance (p < 0.05). In terms of biochemical fatigue indicators, supplementation of 824 or 1648 mg/kg BW/day doses of test substances could effectively reduce blood urea nitrogen concentration and lactate concentration and increase the lactate ratio (p < 0.05) and liver glycogen content post-exercise (p < 0.05). Based on the above results, the combination of physical training and consumption of a dietary supplementation mixture of fermented Tilapia by-products and Monostroma nitidum oligosaccharides could improve the exercise performance of mice and help achieve an anti-fatigue effect.
- Subjects
FATIGUE prevention; LIVER physiology; FERMENTED foods; ANIMAL experimentation; DIETARY supplements; OLIGOSACCHARIDES; FISHES; EXERCISE; AGING; LACTATES; ALGAE; GLYCOGEN; MICE; PHENOTYPES
- Publication
Nutrients, 2021, Vol 13, Issue 5, p1688
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13051688