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- Title
Creatine Supplementation and Brain Health.
- Authors
Roschel, Hamilton; Gualano, Bruno; Ostojic, Sergej M.; Rawson, Eric S.; Kreider, Richard B.
- Abstract
There is a robust and compelling body of evidence supporting the ergogenic and therapeutic role of creatine supplementation in muscle. Beyond these well-described effects and mechanisms, there is literature to suggest that creatine may also be beneficial to brain health (e.g., cognitive processing, brain function, and recovery from trauma). This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine supplementation on brain health in humans. There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain creatine deficits, which could be induced by acute stressors (e.g., exercise, sleep deprivation) or chronic, pathologic conditions (e.g., creatine synthesis enzyme deficiencies, mild traumatic brain injury, aging, Alzheimer's disease, depression). Despite this, the optimal creatine protocol able to increase brain creatine levels is still to be determined. Similarly, supplementation studies concomitantly assessing brain creatine and cognitive function are needed. Collectively, data available are promising and future research in the area is warranted.
- Subjects
BRAIN physiology; CONVALESCENCE; HEALTH status indicators; COGNITION; DIETARY supplements; WOUNDS &; injuries; BRAIN injuries; CREATININE; MEDICAL research; DISEASE risk factors
- Publication
Nutrients, 2021, Vol 13, Issue 2, p586
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13020586