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- Title
Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats.
- Authors
Qiang Yang; Wen-wen Wang; Pu Ma; Zhong-xuan Ma; Meng Hao; Adelusi, Temitope I.; Lei-Du; Xiao-Xing Yin; Qian Lu
- Abstract
Objective(s): Increasing evidence suggests that regular physical exercise improves type 2 diabetes mellitus (T2DM). However, the potential beneficial effects of swimming on insulin resistance and lipid disorder in T2DM, and its underlying mechanisms remain unclear. Materials and Methods: Rats were fed with high fat diet and given a low dosage of Streptozotocin (STZ) to induce T2DM model, and subsequently treated with or without swimming exercise. An 8-week swimming program (30, 60 or 120 min per day, 5 days per week) decreased body weight, fasting blood glucose and fasting insulin. Results: Swimming ameliorated lipid disorder, improved muscular atrophy and revealed a reduced glycogen deposit in skeletal muscles of diabetic rats. Furthermore, swimming also inhibited the activation of Wnt3a/β- catenin signaling pathway, decreased Wnt3a mRNA and protein level, upregulated GSK3β phosphorylation activity and reduced the expression of β-catenin phosphorylation in diabetic rats. Conclusion: The trend of the result suggests that swimming exercise proved to be a potent ameliorator of insulin resistancein T2DM through the modulation of Wnt3a/β-catenin pathway and therefore, could present a promising therapeutic measure towards the treatment of diabetes and its relatives.
- Subjects
LABORATORY rats; TYPE 2 diabetes; INSULIN resistance; SWIMMING training; CATENINS; STREPTOZOTOCIN; MUSCULAR atrophy
- Publication
Iranian Journal of Basic Medical Sciences, 2017, Vol 20, Issue 11, p1220
- ISSN
2008-3866
- Publication type
Article
- DOI
10.22038/IJBMS.2017.9473