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- Title
The effects of whole green tea infusion on mouse urinary bladder chemical carcinogenesis.
- Authors
Henriques, Andreia; Arantes-Rodrigues, Regina; Faustino-Rocha, Ana I.; Teixeira-Guedes, Catarina I.; Pinho-Oliveira, Jacinta; Talhada, Daniela; Teixeira, José H.; Andrade, Andreia; Colaço, Bruno; Paiva-Cardoso, Maria N.; Pires, Maria J.; Ferreira, Ana M. V. D.; Nunes, Fernando M.; Oliveira, Paula A.
- Abstract
Objective(s): Green tea (GT) is one of the most popular beverages worldwide whose beneficial effects on health have been demonstrated. Recent studies suggest that GT may contribute to reduction of cancer risk and progression. The aim of this study was to evaluate the effects of whole GT on urinary bladder chemical carcinogenesis in male and female ICR mice. Materials and Methods: The GT characterization was performed using spectrophotometric methods. Urinary bladder lesions were induced using N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) by gavage during 10 weeks and whole GT (0.5%) was provided ad libitum during 20 weeks. Results: Animals from groups BBN+GT and BBN only developed preneoplastic lesions. Conclusion: We did not observe any effects by GT infusion administration on urinary bladder cancer development.
- Subjects
GREEN tea; CHEMICAL carcinogenesis; GENETIC toxicology; URINARY organs; PSYCHOTROPIC plants
- Publication
Iranian Journal of Basic Medical Sciences, 2014, Vol 17, Issue 2, p145
- ISSN
2008-3866
- Publication type
Article