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- Title
Discovery of Paralogous GnRH and Corazonin Signaling Systems in an Invertebrate Chordate.
- Authors
Guerra, Luis Alfonso Yañez; Zandawala, Meet
- Abstract
Gonadotropin-releasing hormone (GnRH) is a key regulator of reproductive function in vertebrates. GnRH is related to the corazonin (CRZ) neuropeptide which influences metabolism and stress responses in insects. Recent evidence suggests that GnRH and CRZ are paralogous and arose by a gene duplication in a common ancestor of bilaterians. Here, we report the identification and complete characterization of the GnRH and CRZ signaling systems in the amphioxus Branchiostoma floridae. We have identified a novel GnRH peptide (YSYSYGFAP-NH2) that specifically activates two GnRH receptors and a CRZ peptide (FTYTHTW-NH2) that activates three CRZ receptors in B. floridae. The latter appear to be promiscuous, as two CRZ receptors can also be activated by GnRH in the physiological range. Hence, there is a potential for cross-talk between these closely related signaling systems. Discovery of both the GnRH and CRZ signaling systems in one of the closest living relatives of vertebrates provides a framework to discover their roles at the transition from invertebrates to vertebrates.
- Subjects
GONADOTROPIN releasing hormone; AMPHIOXUS; LUTEINIZING hormone releasing hormone receptors; PEPTIDES; CHROMOSOME duplication; PEPTIDE receptors
- Publication
Genome Biology & Evolution, 2023, Vol 15, Issue 7, p1
- ISSN
1759-6653
- Publication type
Article
- DOI
10.1093/gbe/evad108