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- Title
Clinicopathological factors and tumor microenvironment markers predicting watch‐and‐wait discontinuation in 82 patients with follicular lymphoma.
- Authors
Yuda, Sayako; Miyagi Maeshima, Akiko; Taniguchi, Hirokazu; Ito, Yuta; Hatta, Shunsuke; Suzuki, Tomotaka; Makita, Shinichi; Fukuhara, Suguru; Munakata, Wataru; Suzuki, Tatsuya; Maruyama, Dai; Izutsu, Koji
- Abstract
Objectives: In this study, we aimed to determine the clinicopathological factors influencing the treatment‐free period in patients with follicular lymphoma (FL) using a watch‐and‐wait (WW) strategy. Methods: We retrospectively assessed histopathological parameters of 82 patients with FL. Results: The median time from diagnosis to WW discontinuation was 62 months (range, 3‐138), and median follow‐up was 86 months (range, 3‐183). Intermediate or high‐risk Follicular Lymphoma International Prognostic Index score (P =.012), non‐duodenal‐type (P =.011), higher numbers of interfollicular CD4+ (P =.038) and intrafollicular FOXP3+ cells (P =.024) in the tumor microenvironment, and Ki‐67 index ≥10% (P =.031) were significant adverse factors for WW discontinuation in univariate analyses. Conclusion: Patients with adverse factors for WW discontinuation should be carefully observed during follow‐up.
- Subjects
FOLLICULAR lymphoma; TUMOR microenvironment; TUMOR markers; KI-67 antigen; DIAGNOSIS
- Publication
European Journal of Haematology, 2021, Vol 107, Issue 1, p157
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.13637