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- Title
Presence of Mother Reduces Early-Life Social Stress: Linking the Alteration in Hypothalamic-Pituitary-Adrenal Axis and Serotonergic System.
- Authors
Rajan, Koilmani Emmanuvel; Soundarya, Suba; Karen, Christopher; Shanmugapriya, Vasudevan; Radhakrishnan, Karuppasamy
- Abstract
In this study, we examined whether the presence of mother suppresses early-life stressful social experience (SSE)-induced anxiety-like behavior and impairment of short-term memory later in life. On postnatal day (PND)-5, mothers with pups were grouped as follows: (i) control; (ii) maternal separation (MS); (iii) pups with mother experience the presence of a stranger (M+P-ST); and (iv) maternal separated pups experience the presence of a stranger (MSP-ST). Individuals were subjected to light-dark box and spontaneous alternation from PND-29 to 32. We observed that the MSP-ST group exhibits anxiety-like behavior and impairment in short-term memory. Further, SSE significantly elevated the adrenocorticotropic hormone, corticosterone and expression of glucocorticoid receptor (GR) in MSP-ST pups. Similarly, serotonin (5-hydroxytryptamine; 5-HT), dopamine, noradrenaline and expression of serotonin transporter levels were significantly elevated in MSP-ST pups. These observations suggest that during early postnatal days, the pups may recognize strangers by the sense of smell, and the presence of mother reduces the SSE-induced stress.
- Publication
Developmental Neuroscience, 2020, Vol 41, Issue 3/4, p212
- ISSN
0378-5866
- Publication type
Article
- DOI
10.1159/000504508