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- Title
A magnetic polypeptide nanocomposite with pH and near-infrared dual responsiveness for cancer therapy.
- Authors
Zhang, Jie; Gong, Chu; Li, Bingqiang; Shan, Meng; Wu, Guolin
- Abstract
A magnetic polypeptide nanocomposite with pH and near-infrared (NIR) dual responsiveness was developed as a drug carrier for cancer therapy, which was prepared through the self-assembly of FeO superparamagnetic nanoparticles, poly(aspartic acid) derivative (mPEG- g-PDAEAIM) and doxorubicin (DOX) in water. FeO nanoparticles were prepared to provide the superparamagnetic core of nanocomposites for tumor targeting via chemical co-precipitation. The protonable imidazole groups of mPEG- g-PDAEAIM with a pKa of ~7 were accountable for the pH-responsiveness of nanocomposites. The photothermal effect of nanocomposites under the irradiation of NIR laser was induced via the interactions between dopamine groups of mPEG- g-PDAEAIM and FeO superparamagnetic nanoparticles to trigger the drug release. NMR, FT-IR, TEM, hysteresis loop analysis and MRI were utilized to characterize the materials. The DOX loaded nanocomposites exhibited pH-responsive and NIR dependent on/off switchable release profiles. The nanocomposites without drug loading (FeO@mPEG- g-PDAEAIM) showed excellent biocompatibility while DOX loaded nanocomposites caused MCF-7 cells' apoptosis due to the photothermal/chemotherapy combination effects. Overall, the pH and near-infrared dual responsive magnetic nanocomposite had a great potential for cancer therapy.
- Subjects
POLYPEPTIDES; NANOCOMPOSITE materials; MOLECULAR self-assembly; CANCER treatment; PH effect; NEAR infrared spectroscopy
- Publication
Journal of Polymer Research, 2017, Vol 24, Issue 8, p1
- ISSN
1022-9760
- Publication type
Article
- DOI
10.1007/s10965-017-1277-5