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- Title
Preparation of chitosan microspheres loading of 3,5-dihydroxy-4- i-propylstilbene and in vitro release.
- Authors
Gao, Jun-gang; Zhang, Yue; Yu, Yi-feng; Han, Yu-cui; Zhang, Bing-zhu; Gao, Chun-hui
- Abstract
3,5-Dihydroxy-4- i-propylstilbene (DHPS) is a compound expected to be developed into effective drugs for many inflammatory and autoimmune diseases. In order to improve the stablity of DHPS, the cross-linked chitosan (CS) microspheres loading of DHPS were prepared and characterized. The optimal conditions for preparing CS-microspheres loading of DHPS were investigated. The results showed that the CS-microspheres loading of DHPS had spherical shape with diameters between 8 and 12 microns. The entrapment of DHPS in the CS-microspheres was more than 36%. The released percentage of CS-microspheres loading of DHPS in pH 3.6 buffer solution was up to 30.9% within 96 h. In transdermal in vitro release, DHPS kept release within 60 h through rat skin and the released percentage could arrive 76.2%. The CS-microspheres loading of DHPS had excellent stability and ability of sustained release.
- Subjects
CHITOSAN; STILBENE; MICROSPHERES; DRUG development; AUTOIMMUNE diseases; INFLAMMATION; CONTROLLED release drugs
- Publication
Journal of Polymer Research, 2011, Vol 18, Issue 6, p1501
- ISSN
1022-9760
- Publication type
Article
- DOI
10.1007/s10965-010-9555-5