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- Title
Synthesis and antimicrobial activities of gold(I) sulfanylcarboxylates.
- Authors
Barreiro, Elena; Casas, José; Couce, María; Sánchez, Agustín; Seoane, Rafael; Perez-Estévez, Antonio; Sordo, José
- Abstract
Reaction of NaAuCl·HO and thiodiglycol (1:3 molar ratio) with 3-(aryl)-2-sulfanylpropenoic acids, H xspa = [ x:p = 3-phenyl-, f = 3-(2-furyl)-, t = 3-(2-thienyl)-, o- py = 3-(2-pyridyl)-, Clp = 3-(2-chlorophenyl)-, -o-mp = 3-(2-methoxyphenyl)-, -p-mp = 3-(4-methoxyphenyl)-, -o-hp = 3-(2-hydroxyphenyl)-, -p-hp = 3-(4-hydroxyphenyl)-, diBr-o-hp = 3-(3,5-dibromo-2-hydroxyphenyl)] and 2-cyclopentylidene-2-sulfanylacetic acid (Hcpa) in a 1:1 metal/ligand molar ratio gave compounds of the type [Au(H xspa)] or [Au(Hcpa)]. These compounds were reacted with diisopropylamine to afford [HQ][Au( xspa)] or [HQ][Au(cpa)] (HQ = diisopropylammonium) and with NaOH to afford Na[Au( xspa)]·HO and Na[Au(cpa)]·HO. All of the new compounds were isolated and characterised by IR and H and C NMR spectroscopy. The antimicrobial activities of the complexes against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Candida albicans, Pseudomonas aeruginosa and carbapenem-resistant P. aeruginosa were evaluated and compared to those of the equivalent silver(I) complexes. The comparison shows that the gold compounds generally show better activity than the silver analogues against S. aureus and B. subtilis, but low sensitivity against E. coli, P. aeruginosa and C. albicans, suggesting a different mode of antimicrobial action for equivalent silver and gold compounds.
- Subjects
GOLD nanoparticle synthesis; ANTI-infective agents; LIGANDS (Chemistry); CARBOXYLATE derivatives; STAPHYLOCOCCUS aureus; NUCLEAR magnetic resonance spectroscopy
- Publication
Gold Bulletin, 2012, Vol 45, Issue 1, p23
- ISSN
1027-8591
- Publication type
Article
- DOI
10.1007/s13404-011-0040-7