We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Advances in therapeutic options for portal hypertension.
- Authors
Vilaseca, Marina; Guixé-Muntet, Sergi; Fernández-Iglesias, Anabel; Gracia-Sancho, Jordi
- Abstract
Portal hypertension represents one of the major clinical consequences of chronic liver disease, having a deep impact on patients' prognosis and survival. Its pathophysiology defines a pathological increase in the intrahepatic vascular resistance as the primary factor in its development, being subsequently aggravated by a paradoxical increase in portal blood inflow. Although extensive preclinical and clinical research in the field has been developed in recent decades, no effective treatment targeting its primary mechanism has been defined. The present review critically summarizes the current knowledge in portal hypertension therapeutics, focusing on those strategies driven by the disease pathophysiology and underlying cellular mechanisms.
- Publication
Therapeutic Advances in Gastroenterology, 2018, Vol 11, p1
- ISSN
1756-283X
- Publication type
Article
- DOI
10.1177/1756284818811294