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- Title
Synthesis and Comparative Study of Homoisofagomines and Analogues as Glycosidase Inhibitors.
- Authors
Basak, Ranjan Kumar; Vankar, Yashwant D.
- Abstract
The synthesis of polyhydroxyazepanes and their corresponding lactams has been carried out by use of Grubbs cyclisation, to yield the azepane scaffolds, as a key step. A comparative study of glycosidase inhibition by the azepanes and the corresponding lactams with varying stereochemical dispositions, number of hydroxy groups, and side chain structures was carried out.
- Subjects
CHEMICAL synthesis; HETEROCYCLIC compounds; METATHESIS reactions; CHEMICAL reactions; RING formation (Chemistry)
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 4, p844
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201301279