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- Title
Prevalence of hepatitis delta virus among hemodialysis and renal transplant patients.
- Authors
Pierre, Alessandra Maria Mont'Alverne; de Castro Amaral Feldner, Ana Cristina; de Carvalho Filho, Roberto José; de Almeida Lopes, Edmundo Pessoa; Gomes Gouvea, Michele Soares; Pinho, João Renato Rebello; Carvente, Claudia Teresa; Emori, Christini Takemi; da Silva, Genimari Arruda; Gomes Ferraz, Maria Lúcia Cardoso; Feldner, Ana Cristina de Castro Amaral; Carvalho Filho, Roberto José de; Lopes, Edmundo Pessoa de Almeida; Gouvea, Michele Soares Gomes; Silva, Genimari Arruda da; Ferraz, Maria Lúcia Cardoso Gomes
- Abstract
<bold>Introduction: </bold>Hepatitis B virus infection is an important cause of liver disease in hemodialysis patients and renal transplant recipients. Hepatitis Delta virus is a defective virus transmitted by the same route of hepatitis B virus, which requires the helper function of hepatitis B virus. Data about hepatitis B virus/hepatitis delta virus coinfection are scarce and there are no studies regarding the coinfection among hemodialysis patients and renal transplant in our country.<bold>Objective: </bold>This study aimed to investigate the prevalence of hepatitis delta virus infection among hemodialysis patients and renal transplant recipients.<bold>Methods: </bold>Cross-sectional study analyzing virological markers of hepatitis B virus and hepatitis delta virus infection and biochemical and clinical features of liver disease of patients infected with hepatitis B virus in hemodialysis and renal transplant.<bold>Results: </bold>A total of 117 HBsAg-positive patients (46 hemodialysis and 71 renal transplant) were included. The mean age was 48.5 ± 11.8 years and 67% were males. Antiviral therapy was given to 74% of patients. Liver function tests were within the normal range. HBeAg-positive was found in 35% of patients and median hepatitis B virus DNA was 2.98 log (IU/mL). Cirrhosis was detected in 26.5% of patients. The prevalence of anti-hepatitis delta virus total antibody (+) was 1.7% (2/117). None of the 2 patients had active hepatitis delta virus infection, since all samples tested negative for hepatitis delta virus-RNA.<bold>Conclusion: </bold>The results suggest a low prevalence rate of coinfection B and D in hemodialysis and renal transplant recipients in this population.
- Subjects
BRAZIL; HEMODIALYSIS; HEPATITIS D; HEPATITIS B; HEPATITIS viruses; KIDNEY transplantation; VIRAL antigens; DISEASE prevalence; CROSS-sectional method; MIXED infections; DIAGNOSIS
- Publication
International Journal of Artificial Organs, 2018, Vol 41, Issue 3, p171
- ISSN
0391-3988
- Publication type
journal article
- DOI
10.1177/0391398817752989