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- Title
Efficacy of boric acid used to treat experimental vascular graft infection by methicillin-resistant Staphylococcus aureus.
- Authors
Kirişci, Özlem; Kirişci, Mehmet; Metin, Tuba Özcan; Aykan, Duygun Altıntaş; Aral, Murat; Doğaner, Adem; Bayrak, Gülsen
- Abstract
Introduction: We aimed to investigate the efficacy of local boric acid (BA) and teicoplanin in prosthetic vascular graft infection (PVGI) caused by methicillin-resistant Staphylococcus aureus (MRSA) in a rat model. Methodology: Fourty rats were divided into five groups. Group 1 received no treatments (control group); group 2 was uncontaminated polytetrafluoroethylene (PTFE) graft group; group 3 was untreated and the PTFE graft was contaminated with 2×107 CFU/mL MRSA; group 4 received local BA (8 mg/kg) and was contaminated with with 2×107 CFU/mL MRSA; group 5 received local BA (8 mg/kg) and intraperitoneal teikoplanin (10 mg/kg), and was contaminated with 2×107 CFU/mL MRSA; On the 3rd day, grafts and serums were removed for microbiological, histological and serological tests. Results: The amounts of culture growth in groups 4 and 5 were significantly lower compared to group 3 (p < 0.001). TNF-a was significantly higher in Group 3 than the other groups (p = 0.001). There was no significant difference between the groups in serum IL-1 levels (p = 0.138). Monocyte chemotactic protein-1 (MCP-1) was not significantly different between groups 3, 4, and 5, but it was significantly higher than groups 1 and 2 (p < 0.001). The severity of inflammation was significantly higher in group 3 than the other groups, and fibroblastic proliferation, granulation tissue and collagen synthesis were significantly lower (p < 0.05). Conclusions: Our study showed that local BA and combined teicoplanin treatment is effective in preventing PVGI.
- Subjects
METHICILLIN-resistant staphylococcus aureus; STAPHYLOCOCCUS aureus infections; VASCULAR grafts; BORIC acid; GRANULATION tissue
- Publication
Journal of Infection in Developing Countries, 2023, Vol 17, Issue 9, p1317
- ISSN
2036-6590
- Publication type
Article
- DOI
10.3855/jidc.17865