We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Pediatric Bacterial Meningitis Surveillance in the World Health Organization African Region Using the Invasive Bacterial Vaccine-Preventable Disease Surveillance Network, 2011–2016.
- Authors
Mwenda, Jason M; Soda, Elizabeth; Weldegebriel, Goitom; Katsande, Regis; Biey, Joseph Nsiari-Muzeyi; Traore, Tieble; Gouveia, Linda de; Plessis, Mignon du; Gottberg, Anne von; Antonio, Martin; Kwambana-Adams, Brenda; Worwui, Archibald; Gierke, Ryan; Schwartz, Stephanie; Beneden, Chris van; Cohen, Adam; Serhan, Fatima; Lessa, Fernanda C
- Abstract
Background Bacterial meningitis is a major cause of morbidity and mortality in sub-Saharan Africa. We analyzed data from the World Health Organization's (WHO) Invasive Bacterial Vaccine-preventable Diseases Surveillance Network (2011–2016) to describe the epidemiology of laboratory-confirmed Streptococcus pneumoniae (Spn), Neisseria meningitidis , and Haemophilus influenzae meningitis within the WHO African Region. We also evaluated declines in vaccine-type pneumococcal meningitis following pneumococcal conjugate vaccine (PCV) introduction. Methods Reports of meningitis in children <5 years old from sentinel surveillance hospitals in 26 countries were classified as suspected, probable, or confirmed. Confirmed meningitis cases were analyzed by age group and subregion (South-East and West-Central). We described case fatality ratios (CFRs), pathogen distribution, and annual changes in serotype and serogroup, including changes in vaccine-type Spn meningitis following PCV introduction. Results Among 49 844 reported meningitis cases, 1670 (3.3%) were laboratory-confirmed. Spn (1007/1670 [60.3%]) was the most commonly detected pathogen; vaccine-type Spn meningitis cases declined over time. CFR was the highest for Spn meningitis: 12.9% (46/357) in the South-East subregion and 30.9% (89/288) in the West-Central subregion. Meningitis caused by N. meningitidis was more common in West-Central than South-East Africa (321/954 [33.6%] vs 110/716 [15.4%]; P <.0001). Haemophilus influenzae (232/1670 [13.9%]) was the least prevalent organism. Conclusions Spn was the most common cause of pediatric bacterial meningitis in the African region even after reported cases declined following PCV introduction. Sustaining robust surveillance is essential to monitor changes in pathogen distribution and to inform and guide vaccination policies.
- Subjects
SUB-Saharan Africa; CHILDREN'S health; HAEMOPHILUS influenzae; IMMUNIZATION; HEALTH policy; PATHOLOGICAL laboratories; PNEUMOCOCCAL vaccines; PUBLIC health surveillance; STREPTOCOCCUS; WORLD Health Organization; SEROTYPING; SEROTYPES; PNEUMOCOCCAL meningitis; GRAM-negative aerobic bacteria
- Publication
Clinical Infectious Diseases, 2019, Vol 69, pS49
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciz472