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- Title
Solid Phase and Solution Phase Synthesis of Gamma Amino Acid Homo-Oligomers and Mixed Oligomers.
- Authors
Bhaskara Reddy, K. M.; Mallikarjunasarma, Dokka; Bulliraju, Kamana; Sreelatha, Vanjivaka; Kumari, Y. Bharathi; Dandala, Ramesh; Ananda, Kuppanna
- Abstract
An efficient stepwise synthesis of homo-oligomers and mixed oligomers of gabapentin and pregabalin on solid support using Fmoc-protected derivatives and HBTU/HOBt/DIEA as coupling agent is described. The synthesis was also carried out using solution phase methodology. The Gpn/Pgn homo oligomers and mixed oligomers forms C helix in solution as determined by NMR study. Chiral as well as achiral gamma amino acids were used for the synthesis of oligomers in order to investigate the secondary structural preferences. Graphical Abstract: [Figure not available: see fulltext.]
- Subjects
AMINO acids; OLIGOMERS; PEPTIDES; HYDROGEN bonding; AMINOBUTYRIC acid
- Publication
International Journal of Peptide Research & Therapeutics, 2011, Vol 17, Issue 2, p113
- ISSN
1573-3149
- Publication type
Article
- DOI
10.1007/s10989-011-9248-x