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- Title
Anaphase DNA bridges induced by lack of RecQ5 in Drosophila syncytial embryos
- Authors
Sakurai, Haruna; Okado, Misa; Ito, Fumiaki; Kawasaki, Katsumi
- Abstract
Abstract: Drosophila melanogaster RecQ5, a member of the RecQ family, is expressed in early embryos. The loss of maternally-derived RecQ5 leads to spontaneous mitotic defects in syncytial embryos. We demonstrate that the mitotic defects are derived from anaphase DNA bridges. Pairs of daughter nuclei that had been linked by the bridges concurrently exited from the cycle and were eliminated by Chk2-dependent centrosome inactivation. These results suggest that the lack of RecQ5 leads to spontaneous double-stranded DNA breaks (DSBs). RecQ5 may function in the resolution of anaphase DNA bridges during mitosis or in DSB repair during interphase in syncytial Drosophila embryos.
- Subjects
DNA; DROSOPHILA; EMBRYOS; CENTROSOMES; MITOSIS; DNA repair; CELL nuclei; IODIDES; HISTONES
- Publication
FEBS Letters, 2011, Vol 585, Issue 12, p1923
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2011.04.074