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- Title
Regional and Temporal Specificity of Intrinsic Plasticity Mechanisms in Rodent Primary Visual Cortex.
- Authors
Nataraj, Kiran; Turrigiano, Gina
- Abstract
Different neocortical regions are functionally specialized, but whether this specialization is reflected in the forms of plasticity present during developmental critical periods (CPs) is largely unknown. In rodent visual cortex, we recently showed that a form of intrinsic plasticity [LTP of intrinsic excitability (LTP-IE)] in the monocular region of the primary visual cortex (V1M) plays an important role in modulating cortical responsiveness following visual deprivation. Here we ask whether LTP-IE is present and similarly regulated by visual experience in the binocular region of the primary visual cortex (V1B), where inputs from the two eyes compete during the CP. In contrast to V1M, where LTP-IE is present throughout the CP, in V1B LTP-IE was only transiently expressed at the onset of the CP. Also distinct from V1M, brief monocular deprivation (MD) was unable to modulate LTP-IE magnitude in V1B, and even binocular deprivation (the equivalent of MD in V1M) could only influence LTP-IE expression during a narrow time window at the peak of the CP. Finally, we asked whether these differences depend on differences in sensory activation of the two areas during development.MDof ipsilateral inputs from before eye opening (to reduce competitive interactions) did not affect the pattern of LTP-IE expression in V1B. Further, the differences in plasticity in the two cortical areas persisted when animals were reared in the dark to remove all patterned visual input. Thus neocortical LTP-IE expression shows dramatic regional and temporal differentiation, and these differences are not driven by differences in sensory experience.
- Subjects
NEUROPLASTICITY; LABORATORY rodents; PRIMARY care; VISUAL cortex; GENE expression; GENETIC regulation; NEURON development
- Publication
Journal of Neuroscience, 2011, Vol 31, Issue 49, p17932
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.4455-11.2011