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- Title
Downregulation of Dendritic I<sub>h</sub> in CA1 Pyramidal Neurons after LTP.
- Authors
Campanac, Emilie; Daoudal, Gaël; Ankri, Norbert; Debanne, Dominique
- Abstract
Hyperpolarization-activated (h)-channels occupy a central position in dendritic function. Although it has been demonstrated that these channels are upregulated after large depolarizations to reduce dendritic excitation, it is not clear whether they also support other forms of long-term plasticity. We show here that nearly maximal long-term potentiation (LTP) induced by theta-burst pairing produced upregulation in h-channel activity inCA1pyramidal neurons. In contrast, moderateLTPinduced by spike-timing-dependent plasticity or high-frequency stimulation (HFS) downregulated the h-current (Ih ) in the dendrites. After HFS-induced LTP, the h-conductance (Gh ) was reduced without changing its activation. Pharmacological blockade of Ih had no effect on LTP induction, but occluded EPSP-to-spike potentiation, an input-specific facilitation of dendritic integration. Dynamic-clamp reduction of Gh locally in the dendrite mimicked the effects of HFS and enhanced synaptic integration in an input-selective way. We conclude that dendritic Ih is locally downregulated after induction of nonmaximal LTP, thus facilitating integration of the potentiated input.
- Subjects
NEUROSCIENCES; MATERIAL plasticity; NEURONS; DENDRITES; NERVOUS system
- Publication
Journal of Neuroscience, 2008, Vol 28, Issue 34, p8635
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.1411-08.2008