We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Bivalent Coronavirus Disease 2019 Vaccine Antibody Responses to Omicron Variants Suggest That Responses to Divergent Variants Would Be Improved With Matched Vaccine Antigens.
- Authors
Wang, Wei; Goguet, Emilie; Paz, Stephanie; Vassell, Russell; Pollett, Simon; Mitre, Edward; Weiss, Carol D
- Abstract
We compared neutralizing antibody responses to BA.4/5, BQ.1.1, XBB, and XBB.1.5 Omicron severe acute respiratory syndrome coronavirus 2 variants after a bivalent or ancestral coronavirus disease 2019 (COVID-19) messenger RNA booster vaccine or postvaccination infection. We found that the bivalent booster elicited moderately high antibody titers against BA.4/5 that were approximately 2-fold higher against all Omicron variants than titers elicited by the monovalent booster. The bivalent booster elicited low but similar titers against both XBB and XBB.1.5 variants. These findings inform risk assessments for future COVID-19 vaccine recommendations and suggest that updated COVID-19 vaccines containing matched vaccine antigens to circulating divergent variants may be needed.
- Subjects
COVID-19; SARS-CoV-2; SARS-CoV-2 Omicron variant; CORONAVIRUS diseases; VACCINE effectiveness; ANTIBODY formation
- Publication
Journal of Infectious Diseases, 2023, Vol 228, Issue 4, p439
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad111