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- Title
Codelivery of Antigens and Adjuvant in Polymeric Nanoparticles Coated With Native Parasite Membranes Induces Protective Mucosal Immunity Against Giardia lamblia.
- Authors
Zhou, Jiarong; Miyamoto, Yukiko; Ihara, Sozaburo; Kroll, Ashley V; Nieskens, Noelle; Tran, Vivien N; Hanson, Elaine M; Fang, Ronnie H; Zhang, Liangfang; Eckmann, Lars
- Abstract
The protozoan pathogen Giardia lamblia is an important worldwide cause of diarrheal disease and malabsorption. Infection is managed with antimicrobials, although drug resistance and treatment failures are a clinical challenge. Prior infection provides significant protection, yet a human vaccine has not been realized. Individual antigens can elicit partial protection in experimental models, but protection is weaker than after prior infection. Here, we developed a multivalent nanovaccine by coating membranes derived from the parasite onto uniform and stable polymeric nanoparticles loaded with a mucosal adjuvant. Intranasal immunization with the nanovaccine induced adaptive immunity and effectively protected mice from G. lamblia infection.
- Publication
Journal of Infectious Diseases, 2022, Vol 226, Issue 2, p319
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiac074