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- Title
CMV-Specific Cell-Mediated Immunity Predicts a High Level of CMV Replication After Prophylaxis Withdrawal in Lung Transplant Recipients.
- Authors
Donadeu, Laura; Revilla-López, Eva; Jarque, Marta; Crespo, Elena; Torija, Alba; Bravo, Carles; Arcos, Ibai Los; Meneghini, Maria; Favà, Alex; Román, Antonio; Monforte, Víctor; Bestard, Oriol; Los Arcos, Ibai
- Abstract
Monitoring cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) is useful in predicting late-onset CMV infection after solid organ transplantation, but few data have been reported after lung transplantation (LT). CMV CMI against 2 CMV antigens (IE-1, pp65) was evaluated in 60 seropositive LT at 6-month prophylaxis withdrawal. LT with late-onset CMV infection showed significantly lower (IE-1)CMV CMI than patients without (P = .045), and was more evident in patients developing high viral loads (P = .010). (IE-1)CMV CMI independently predicted high first late-onset viral replication (odds ratio, 4.358; 95% confidence interval, 1.043-18.215). CMV-specific CMI may be useful in CMV preventive strategies after LT.
- Subjects
CYTOMEGALOVIRUS diseases; CELLULAR immunity; LUNG transplantation; TRANSPLANTATION of organs, tissues, etc.; PREVENTIVE medicine; CYTOMEGALOVIRUS disease prevention; CYTOMEGALOVIRUSES; RESEARCH; LUNGS; RESEARCH methodology; KIDNEY transplantation; ANTIVIRAL agents; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; RESEARCH funding
- Publication
Journal of Infectious Diseases, 2021, Vol 224, Issue 3, p526
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa727